rapK
168
response regulator aspartate phosphatase, controls [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity
locus
BSU_18910
Molecular weight
43.68 kDa
pI
5.06
function
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity
product
response regulator aspartate phosphatase
essential
no
synonyms
rapK, yobG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,062,150 → 2,063,265
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The protein
Catalyzed reaction/ biological activity
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity [Pubmed|16816200]
Protein family
[wiki|RAP family] (according to UniProt)
[wiki|Domains]
six [wiki|TPR repeat|tetratrichopeptide repeats] (according to UniProt)
Structure
[PDB|4I1A] ([protein|A208B4564A50D7BE2630DE40E8FAAF3C16236EE4|rapI], 30% identity) [pubmed|23526881]
[AF|O34930]
Effectors of protein activity
binding of [protein|886C1BAE024A9D1A6C7C4F16E5251D5427B8D41E|phrK] inhibits RapK activity [Pubmed|16816200]
Expression and Regulation
Operons
genes
[gene|C8BF3815578293542D14811C60F4CA78AACF73EB|rapK]-[gene|886C1BAE024A9D1A6C7C4F16E5251D5427B8D41E|phrK]
description
[Pubmed|11466295]
regulation
induced under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|25666134]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|25666134], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|11466295], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Biological materials
Mutant
BKE18910 (Δ[gene|C8BF3815578293542D14811C60F4CA78AACF73EB|rapK]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTAAACCCCTCTTTCTG, downstream forward: _UP4_ATGAATCAGGTGGAGGGAAT
BKK18910 (Δ[gene|C8BF3815578293542D14811C60F4CA78AACF73EB|rapK]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTAAACCCCTCTTTCTG, downstream forward: _UP4_ATGAATCAGGTGGAGGGAAT
References
Reviews
Original Publications
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Time of last update: 2024-04-25 11:44:10
Author of last update: Jstuelk