rplJ

168

ribosomal protein uL10

locus: BSU_01040

Molecular weight: 17.89 kDa

pI: 5.49

Protein length: 166 aa

Gene length: 501 bp

function: translation

product: ribosomal protein L10 (uL10)

essential: yes

synonyms: rplJ

List of homologs in different organisms, belongs to COG0244 (Galperin et al., 2021)

Gene

Coordinates: 120,061 120,561

Phenotypes of a mutant

• essential [Pubmed|23002217,12682299]

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The protein

Protein family

• Universal [wiki|ribosomal protein] uL10 family (single member, according to UniProt)

Structure

• [PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
• [AF|P42923]

[wiki|Interactions]

• interact directly with [protein|E72910604D3DC2A62AE8A951F55570EA2838B250|L12] [pubmed|19024552]

[wiki|Localization]

• [wiki|ribosome] (according to UniProt)

Additional information

• belongs to the 100 most abundant proteins [PubMed|15378759]
• this ribosomal protein is lacking in some organisms with very small genomes [pubmed|33753464]

Expression and Regulation

Operons

• genes: [gene|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[gene|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]

  description: [Pubmed|26101249]

  regulation

  • termination/ antitermination ([protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|L10]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|L12]₄ complex) [Pubmed|26101249]

  regulatory mechanism

  • [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]: termination, at excess of the [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]₄ complex, in [regulon|protein:5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ regulon]
  • stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
  • [protein|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]: termination, at excess of the [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]₄ complex, in [regulon|protein:E72910604D3DC2A62AE8A951F55570EA2838B250|rplL regulon]

• genes: [gene|F94A1C14912F35ADB4C611AA17D55268CC26160D|rplK]-[gene|44D4CE353E1E532664A508CBE8B49AC8BB861B53|rplA]-[gene|E4D89640D0F0A31A2814D20FB5425FDB0B46A43D|BSU_misc_RNA_3]-[gene|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[gene|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]

  description: [pubmed|22383849]

  regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

  regulatory mechanism

  • stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]

References

• 19653700,23002217,15378759,18247578,26101249,25903689,19024552,33753464