spoIIQ

spoIIQ
168

component of the [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]-[protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ] type III secretion system residing in the forespore membrane, required for anchoring of proteins on both sides of the sporulation septum, required for localization and stability of [protein|7C8DFE00A2B2B30CC8BEB35055D92CC2E4128F3A|spoIIE]

locus
BSU_36550
Molecular weight
30.96 kDa
pI
4.47
Protein length
Gene length
function
forespore encasement by the spore coat
product
part of the transmembrane channel linking the mother cell and the forespore
essential
no
synonyms
spoIIQ, ywnI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5820 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,759,702  3,760,553
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The protein
Catalyzed reaction/ biological activity
required for forespore encasement by the spore coat [Pubmed|22171814]
required for the recruitment of [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH] to the [wiki|sporulation] septum on the mother cell side [Pubmed|23834622]
required for the proper localization and stability of [protein|7C8DFE00A2B2B30CC8BEB35055D92CC2E4128F3A|spoIIE] [Pubmed|26929302]
Structure
[PDB|3UZO]; [PDB|3TUF] (the [protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]-[protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH] pore forming complex)  [Pubmed|22431604,22431613]
[AF|P71044]
[wiki|Localization]
membrane protein, forms a transmembrane channel linking the mother cell and the forespore (with [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]) [Pubmed|22431604,22431613,22171814]
septal membranes on the forespore side [Pubmed|27381174]
proper [wiki|localization] requires [protein|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH], [protein|AA519F0D7DC94165C2CF5F7E230502D884898B71|gerM] and degradation of septal peptidoglycan by the cell wall hydrolases [protein|AAC4BF6FA80115AB90D2B161C1D5383625953616|spoIID] and [protein|C9817A54C8E72193280E393D7BD3375BD1751738|spoIIP] [Pubmed|23834622]
Expression and Regulation
Operons
genes
[gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]
description
[Pubmed|9140963]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325,15699190,9140963]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325,9140963], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
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[gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]

2024-02-15 19:53:18

ghost

44

4350f9e1d2ea60222fe48fe847c4ab0f46f3180c

9366D760CD732360053BB0564804339107E7AA25

Biological materials
Mutant
BKE36550 ([gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36550 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCATCACCTCAGC,  downstream forward: _UP4_TAATGAAGAAAACGTCTATC
BKK36550 ([gene|3282D2C25468776881778006F182FCF322C4821D|spoIIQ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36550 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGTTTCATCACCTCAGC,  downstream forward: _UP4_TAATGAAGAAAACGTCTATC
References
Reviews
23944268,25105965,31350897,32660383,33651833,35638784
Original Publications
18812514,15752199,18077456,18485064,15574594,15044948,15882622,19609349,9140963,20444098,17121846,18160039,21097616,16497325,15699190,22431613,22171814,23834622,22431604,23859254,25356555,26929302,27381174,33383000,33523946

3282D2C25468776881778006F182FCF322C4821D

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Time of last update: 2024-03-28 08:39:35

Author of last update: Jstuelk