pth

168

peptidyl-tRNA hydrolase, general stress protein

locus: BSU_00530

Molecular weight: 20.73 kDa

pI: 5.58

Protein length: 188 aa

Gene length: 567 bp

function: ribosome-associated quality control

product: peptidyl-tRNA hydrolase

essential: yes

ec: 3.1.1.29

synonyms: spoVC

List of homologs in different organisms, belongs to COG0193 (Galperin et al., 2021)

Gene

Coordinates: 59,504 → 60,070

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Catalyzed reaction/ biological activity

• H₂O + N-acyl-L-α-aminoacyl-tRNA --> N-acyl-L-amino acid + H⁺ + tRNA (according to UniProt)

Protein family

• PTH family (single member, according to UniProt)

Structure

• [PDB|4QT4] (from ''Streptococcus pyogenes'', 48% identity) [Pubmed|25389518]
• [AF|P37470]

[wiki|Localization]

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|40624E9FC30D75D172EF098C7FAC77B2573CC129|ctc]-[gene|FE7859E98F26E532AE02CD71B42B845BADBCF06E|pth]-[gene|C595D32D98723E93AF26B5C864FD61AF4739E069|fin]

  description: [pubmed|22383849]

  regulation

  • induced under stress conditions ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]) [pubmed|15805528]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]

References

• 11544224,12100553,25389518,35638784