tagG

168

[wiki|ABC transporter] for teichoic acid translocation (permease)

locus: BSU_35710

Molecular weight: 32.03 kDa

pI: 9.56

Protein length: 275 aa

Gene length: 828 bp

function: [category|SW.2.6.1.3|Biosynthesis of teichoic acid]

product: [wiki|ABC transporter] for teichoic acid translocation (permease)

essential: yes

synonyms: tagG

List of homologs in different organisms, belongs to COG1682 (Galperin et al., 2021)

Gene

Coordinates: 3,675,167  3,675,994

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Protein family

• [wiki|ABC-2 integral membrane protein family] (according to UniProt)

[wiki|Domains]

• [wiki|ABC transmembrane type-2 domain] (aa 35-267) (according to UniProt)

Structure

• [PDB|6JBH] (the complex corresponding to [protein|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[protein|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH] from Alicyclobacillus herbarius, 41.7% identity) [pubmed|32184247]
• [AF|P42953]

[wiki|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]-[gene|88028A5F3520CB6DAB014412974EB59CC5D226DD|tagE]-[gene|E730E41546298960A4B907FCB7F36C495AA9602B|tagF]-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]

  description: [Pubmed|22383849]

  regulation

  • repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]

  regulatory mechanism

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: repression, [Pubmed|9457886], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: activation, [Pubmed|12950927], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7581998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

Biological materials

GFP fusion

• 3512 [gene|0467447B10EE7C1FDF86022AB6FBDBABFD32A9E5|trpC]2 [gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]::pSG5322 (cat P_xyl-gfp-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]1-346) [pubmed|18156271], available in [wiki|Dirk Jan Scheffers]' lab and in the [http://bgsc.org BGSC]

References

Reviews

• 24024634

Original Publications

• 18156271,10092453,7565096,21280653,22383849,32184247,35647874