yaaJ

yaaJ
168

tRNA specific adenosine deaminase

locus
BSU_00180
Molecular weight
17.61 kDa
pI
5.64
Protein length
Gene length
function
tRNA modification
product
tRNA specific adenosine deaminase
essential
no
synonyms
yaaJ, tadA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0590 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
25,852  26,337
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The protein
Catalyzed reaction/ biological activity
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) (according to UniProt)
adenosine34 in tRNA + H+ + H2O --> inosine34 in tRNA + NH4+ (according to UniProt)
Protein family
[wiki|Cytidine and deoxycytidylate deaminase family] (according to UniProt)
[wiki|Domains]
[wiki|CMP/dCMP-type deaminase domain] (aa 2-120) (according to UniProt)
Structure
[PDB|2B3J] (the protein of ''Staphylococcus aureus'', complex with RNA) [Pubmed|16415880]
[AF|P21335]
Expression and Regulation
Operons
genes
[gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]-[gene|097C817A5A3E31F73F6ABC4AA95852A64E43A057|scr]
description
null
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, (both promoters), in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]→[gene|097C817A5A3E31F73F6ABC4AA95852A64E43A057|scr]

2024-03-05 02:12:23

ghost

78

b2d28cf402e740ffdb8d72c8cd99dd7c5f187533

7A6D368CD211CDB194D1980F4321F881B55AD15E

Biological materials
Mutant
MGNA-B891 (yaaJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1890 NBRP B. subtilis, Japan]
BKE00180 ([gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAAGGATAAGCTCTCTTT,  downstream forward: _UP4_TAGTACGGTTGCAATTTTTA
BKK00180 ([gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAAGGATAAGCTCTCTTT,  downstream forward: _UP4_TAGTACGGTTGCAATTTTTA
References
19087206,12110595,16415880,28864459,37628567

5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB

Page visits: 4044

Time of last update: 2024-03-28 21:20:56

Author of last update: Jstuelk