yisQ

168

probable multidrug resistance protein

locus: BSU_10820

Molecular weight: 49.85 kDa

pI: 10.18

Protein length: 455 aa

Gene length: 1368 bp

function: unknown

product: putative multidrug exporter

essential: no

synonyms: yisQ, yucE

List of homologs in different organisms, belongs to COG0534 (Galperin et al., 2021)

Gene

Coordinates: 1,160,776  1,162,143

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The protein

Protein family

• [wiki|MOP exporter family]
• [wiki|multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family] (accordinig to UniProt)

Structure

• [PDB|3VVO] (MATE multidrug exporter from Pyrococcus furiosus, 23% identity) [pubmed|23535598]
• [AF|O07940]

[wiki|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|5050D0049B87C9FF2ACCE45BD13FDA0227AAB804|yisQ]

  description: [pubmed|22383849]

Biological materials

Mutant

• MGNA-B182 (yisQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1181 NBRP B. subtilis, Japan]
• BKE10820 ([gene|5050D0049B87C9FF2ACCE45BD13FDA0227AAB804|yisQ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCGTGTCTAACCCCTTTC,  downstream forward: _UP4_TAACACCCGGCTCAATCAAG
• BKK10820 ([gene|5050D0049B87C9FF2ACCE45BD13FDA0227AAB804|yisQ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCGTGTCTAACCCCTTTC,  downstream forward: _UP4_TAACACCCGGCTCAATCAAG

References

Research papers

• 23535598