Difference between revisions of "OxdC"

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Revision as of 20:49, 15 July 2009

  • Description: oxalate decarboxylase

Gene name oxdC
Synonyms yvrK
Essential no
Product oxalate decarboxylase
Function unknown
MW, pI 43 kDa, 5.101
Gene length, protein length 1155 bp, 385 aa
Immediate neighbours yvrJ, yvrL
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
OxdC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU33240

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Oxalate = formate + CO2 (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s): OxdD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): requires Mn(II) for activity PubMed
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation: induced by acidic growth conditions PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Ellen W Moomaw, Alexander Angerhofer, Patricia Moussatche, Andrew Ozarowski, Inés García-Rubio, Nigel G J Richards
Metal dependence of oxalate decarboxylase activity.
Biochemistry: 2009, 48(26);6116-25
[PubMed:19473032] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, John D Helmann, Haike Antelmann
The YvrI alternative sigma factor is essential for acid stress induction of oxalate decarboxylase in Bacillus subtilis.
J Bacteriol: 2009, 191(3);931-9
[PubMed:19047353] [WorldCat.org] [DOI] (I p)

Shawn R MacLellan, Tina Wecke, John D Helmann
A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis.
Mol Microbiol: 2008, 69(4);954-67
[PubMed:18573182] [WorldCat.org] [DOI] (I p)

Haike Antelmann, Stefanie Töwe, Dirk Albrecht, Michael Hecker
The phosphorus source phytate changes the composition of the cell wall proteome in Bacillus subtilis.
J Proteome Res: 2007, 6(2);897-903
[PubMed:17269748] [WorldCat.org] [DOI] (P p)

Ruchi Anand, Pieter C Dorrestein, Cynthia Kinsland, Tadhg P Begley, Steven E Ealick
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.
Biochemistry: 2002, 41(24);7659-69
[PubMed:12056897] [WorldCat.org] [DOI] (P p)

A Tanner, L Bowater, S A Fairhurst, S Bornemann
Oxalate decarboxylase requires manganese and dioxygen for activity. Overexpression and characterization of Bacillus subtilis YvrK and YoaN.
J Biol Chem: 2001, 276(47);43627-34
[PubMed:11546787] [WorldCat.org] [DOI] (P p)