Difference between revisions of "SipU"

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(Expression and regulation)
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* '''Protein family:''' peptidase S26 family (according to Swiss-Prot)
 
* '''Protein family:''' peptidase S26 family (according to Swiss-Prot)
  
* '''Paralogous protein(s):'''
+
* '''Paralogous protein(s):''' [[SipS]], [[SipT]], [[SipV]]
  
 
=== Extended information on the protein ===
 
=== Extended information on the protein ===
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=Labs working on this gene/protein=
 
=Labs working on this gene/protein=
 +
 +
[[Jan Maarten van Dijl]], Groningen, Netherlands
  
 
=Your additional remarks=
 
=Your additional remarks=

Revision as of 19:28, 18 November 2009

  • Description: signal peptidase I

Gene name sipU
Synonyms ycsB
Essential no
Product signal peptidase I
Function protein secretion
MW, pI 21 kDa, 9.844
Gene length, protein length 561 bp, 187 aa
Immediate neighbours ycsA, yczH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SipU context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU04010

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
  • Protein family: peptidase S26 family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: sipU (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Your additional remarks

References

H Tjalsma, A Bolhuis, M L van Roosmalen, T Wiegert, W Schumann, C P Broekhuizen, W J Quax, G Venema, S Bron, J M van Dijl
Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases.
Genes Dev: 1998, 12(15);2318-31
[PubMed:9694797] [WorldCat.org] [DOI] (P p)

H Tjalsma, M A Noback, S Bron, G Venema, K Yamane, J M van Dijl
Bacillus subtilis contains four closely related type I signal peptidases with overlapping substrate specificities. Constitutive and temporally controlled expression of different sip genes.
J Biol Chem: 1997, 272(41);25983-92
[PubMed:9325333] [WorldCat.org] [DOI] (P p)