Difference between revisions of "SlrR"

From SubtiWiki
Jump to: navigation, search
Line 1: Line 1:
* '''Description:''' transcriptional activator of competence development and sporulation genes, represses [[SigD]]-dependent flagellar genes, antagonist of [[SlrA]] <br/><br/>
+
* '''Description:''' transcriptional activator of competence development and sporulation genes, represses [[SigD]]-dependent flagellar genes, antagonist of [[SlrA]] and [[SinR]]<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
Line 12: Line 12:
 
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription regulator, [[SlrA]] antagonist
 
|style="background:#ABCDEF;" align="center"| '''Product''' || transcription regulator, [[SlrA]] antagonist
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of initiation of biofilm formation
+
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of initiation of biofilm formation and of autolysis
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]'''
Line 54: Line 54:
 
=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:''' binding and concomintant inactivation of [[SlrA]] results in release of [[SinR]] from the [[SinR]]-[[SrlA]] complex and subsequent induction of [[SinR]]-controlled genes and operons for biofilm formation {{PubMed|19788541}}
+
* '''Catalyzed reaction/ biological activity:''' binding and concomintant inactivation of [[SlrA]] results in release of [[SinR]] from the [[SinR]]-[[SrlA]] complex and subsequent induction of [[SinR]]-controlled genes and operons for biofilm formation {{PubMed|19788541}}, repression of transcription of  ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytF]]'' {{PubMed|20351052}}
  
 
* '''Protein family:'''
 
* '''Protein family:'''
Line 70: Line 70:
 
* '''Cofactor(s):'''
 
* '''Cofactor(s):'''
  
* '''Effectors of protein activity:'''
+
* '''Effectors of protein activity:''' interaction with [[SinR]] triggers binding of SlrR to the promoters of ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytF]]'', resulting in their repression {{PubMed|20351052}}
  
 
* '''Interactions:''' [[SlrA]]-[[SlrR]] {{PubMed|19788541}}, [[SinR]]-[[SlrR]] {{PubMed|20351052}}
 
* '''Interactions:''' [[SlrA]]-[[SlrR]] {{PubMed|19788541}}, [[SinR]]-[[SlrR]] {{PubMed|20351052}}
Line 123: Line 123:
 
=References=
 
=References=
  
<pubmed>18430133,18647168, 19767430, 19788541 </pubmed>
+
<pubmed>18430133,18647168, 19767430, 19788541 20351052 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:36, 31 March 2010

  • Description: transcriptional activator of competence development and sporulation genes, represses SigD-dependent flagellar genes, antagonist of SlrA and SinR

Gene name slrR
Synonyms yveJ, slr
Essential no
Product transcription regulator, SlrA antagonist
Function regulation of initiation of biofilm formation and of autolysis
Regulation of this protein in SubtiPathways:
Biofilm
MW, pI 17 kDa, 9.63
Gene length, protein length 456 bp, 152 aa
Immediate neighbours epsA, pnbA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Slr context.gif
This image was kindly provided by SubtiList









The gene

Basic information

  • Locus tag: BSU34380

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binding and concomintant inactivation of SlrA results in release of SinR from the SinR-SrlA complex and subsequent induction of SinR-controlled genes and operons for biofilm formation PubMed, repression of transcription of lytA-lytB-lytC and lytF PubMed
  • Protein family:
  • Paralogous protein(s): SinR

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: interaction with SinR triggers binding of SlrR to the promoters of lytA-lytB-lytC and lytF, resulting in their repression PubMed
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yunrong Chai, Thomas Norman, Roberto Kolter, Richard Losick
An epigenetic switch governing daughter cell separation in Bacillus subtilis.
Genes Dev: 2010, 24(8);754-65
[PubMed:20351052] [WorldCat.org] [DOI] (I p)

Yunrong Chai, Roberto Kolter, Richard Losick
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.
Mol Microbiol: 2009, 74(4);876-87
[PubMed:19788541] [WorldCat.org] [DOI] (I p)

Ewan J Murray, Mark A Strauch, Nicola R Stanley-Wall
SigmaX is involved in controlling Bacillus subtilis biofilm architecture through the AbrB homologue Abh.
J Bacteriol: 2009, 191(22);6822-32
[PubMed:19767430] [WorldCat.org] [DOI] (I p)

Kazuo Kobayashi
SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 69(6);1399-410
[PubMed:18647168] [WorldCat.org] [DOI] (I p)

Frances Chu, Daniel B Kearns, Anna McLoon, Yunrong Chai, Roberto Kolter, Richard Losick
A novel regulatory protein governing biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 68(5);1117-27
[PubMed:18430133] [WorldCat.org] [DOI] (I p)