Difference between revisions of "RapH"

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(Expression and regulation)
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* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[RghR]]: transcription repression {{PubMed|16553878}}
 
** [[RghR]]: transcription repression {{PubMed|16553878}}
 +
** [[ComK]]: transcription activation {{PubMed|11948146,11918817}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 12:04, 19 May 2010

Gene name rapH
Synonyms yeeH, yzqA
Essential no
Product response regulator aspartate phosphatase
Function control of sporulation initiation and ComA activity
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 49 kDa, 6.121
Gene length, protein length 1293 bp, 431 aa
Immediate neighbours yeeG, yeeI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RapH context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU06830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binds to and thereby inhibits ComA activity PubMed; in addition, RapH dephosphorylates Spo0F-P and thereby controls the phosphorelay PubMed
  • Protein family: RAP family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Wiep Klaas Smits, Cristina Bongiorni, Jan-Willem Veening, Leendert W Hamoen, Oscar P Kuipers, Marta Perego
Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis.
Mol Microbiol: 2007, 65(1);103-20
[PubMed:17581123] [WorldCat.org] [DOI] (P p)

Kentaro Hayashi, Tsukahara Kensuke, Kazuo Kobayashi, Naotake Ogasawara, Mitsuo Ogura
Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon.
Mol Microbiol: 2006, 59(6);1714-29
[PubMed:16553878] [WorldCat.org] [DOI] (P p)