Difference between revisions of "HypO"

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* '''Description:''' NAD(P)H-flavin oxidoreductase <br/><br/>
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* '''Description:''' NAD(P)H-flavin nitroreductase <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || NAD(P)H-flavin oxidoreductase
+
|style="background:#ABCDEF;" align="center"| '''Product''' || NAD(P)H-flavin nitroreductase
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
 
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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=References=
 
=References=
 
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<pubmed> 20727918 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:50, 24 August 2010

  • Description: NAD(P)H-flavin nitroreductase

Gene name yfkO
Synonyms
Essential no
Product NAD(P)H-flavin nitroreductase
Function unknown
MW, pI 25 kDa, 5.667
Gene length, protein length 663 bp, 221 aa
Immediate neighbours treR, yfkN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YfkO context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU07830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: nitroreductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: ykfO (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

G A Prosser, A V Patterson, D F Ackerley
uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.
J Biotechnol: 2010, 150(1);190-4
[PubMed:20727918] [WorldCat.org] [DOI] (I p)