Difference between revisions of "FtsY"

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(Extended information on the protein)
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|style="background:#ABCDEF;" align="center"| '''Product''' || signal recognition particle
 
|style="background:#ABCDEF;" align="center"| '''Product''' || signal recognition particle
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || protein secretion
+
|style="background:#ABCDEF;" align="center"|'''Function''' || [[protein secretion]]
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/FtsY FtsY]
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
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* '''[[SubtInteract|Interactions]]:'''  
 
* '''[[SubtInteract|Interactions]]:'''  
 +
** [[Ffh]]-[[FtsY]] {{PubMed|21330537}}
  
 
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
 
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
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* '''Structure:'''
 
* '''Structure:'''
 +
** [http://www.pdb.org/pdb/explore/explore.do?structureId=2XXA 2XXA] (complex [[Ffh]]-[[FtsY]]-[[Scr]] RNA, from ''E. coli'') {{PubMed|21330537}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P51835 P51835]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P51835 P51835]
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=References=
 
=References=
  
<pubmed>16705751,15995216 ,11021934 </pubmed>
+
<pubmed>16705751,15995216 ,11021934 21330537</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:12, 8 November 2011

  • Description: signal recognition particle

Gene name ftsY
Synonyms srb
Essential no
Product signal recognition particle
Function protein secretion
Interactions involving this protein in SubtInteract: FtsY
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 36 kDa, 5.081
Gene length, protein length 987 bp, 329 aa
Immediate neighbours smc, ylqB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FtsY context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

protein secretion, sporulation proteins, membrane proteins

This gene is a member of the following regulons

GerE regulon, SigK regulon

The gene

Basic information

  • Locus tag: BSU15950

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: GTP-binding SRP family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed during vegetative growth and during sporulation in the mother cell (SigK, GerE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Sandro F Ataide, Nikolaus Schmitz, Kuang Shen, Ailong Ke, Shu-ou Shan, Jennifer A Doudna, Nenad Ban
The crystal structure of the signal recognition particle in complex with its receptor.
Science: 2011, 331(6019);881-6
[PubMed:21330537] [WorldCat.org] [DOI] (I p)

Geeske Zanen, Haike Antelmann, Rob Meima, Jan D H Jongbloed, Marc Kolkman, Michael Hecker, Jan Maarten van Dijl, Wim J Quax
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis.
Proteomics: 2006, 6(12);3636-48
[PubMed:16705751] [WorldCat.org] [DOI] (P p)

Aileen Rubio, Xin Jiang, Kit Pogliano
Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa.
J Bacteriol: 2005, 187(14);5000-2
[PubMed:15995216] [WorldCat.org] [DOI] (P p)

Hiroshi Kakeshita, Akihiro Oguro, Reiko Amikura, Kouji Nakamura, Kunio Yamane
Expression of the ftsY gene, encoding a homologue of the alpha subunit of mammalian signal recognition particle receptor, is controlled by different promoters in vegetative and sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 10);2595-2603
[PubMed:11021934] [WorldCat.org] [DOI] (P p)