FtsY

• Description: signal recognition particle
  
  

Gene name	ftsY
Synonyms	srb
Essential	no
Product	signal recognition particle
Function	protein secretion
Gene expression levels in SubtiExpress: ftsY
Interactions involving this protein in SubtInteract: FtsY
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	36 kDa, 5.081
Gene length, protein length	987 bp, 329 aa
Immediate neighbours	smc, ylqB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, sporulation proteins, membrane proteins

This gene is a member of the following regulons

GerE regulon, SigK regulon

The gene

Basic information

• Locus tag: BSU15950

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: GTP-binding SRP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Ffh-FtsY in the signal recognition particle PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:
  • 2XXA (complex Ffh-FtsY-Scr RNA, from E. coli) PubMed

• UniProt: P51835

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rnc-smc-ftsY PubMed
  • ftsY PubMed

• Expression browser: ftsY PubMed

• Sigma factor:
  • rnc: SigA PubMed
  • ftsY: SigK PubMed

• Regulation:
  • expressed during vegetative growth and during sporulation in the mother cell (SigK, GerE) PubMed

• Regulatory mechanism:
  • GerE: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Sandro F Ataide, Nikolaus Schmitz, Kuang Shen, Ailong Ke, Shu-ou Shan, Jennifer A Doudna, Nenad Ban
The crystal structure of the signal recognition particle in complex with its receptor.
Science: 2011, 331(6019);881-6
[PubMed:21330537] [WorldCat.org] [DOI] (I p)

Geeske Zanen, Haike Antelmann, Rob Meima, Jan D H Jongbloed, Marc Kolkman, Michael Hecker, Jan Maarten van Dijl, Wim J Quax
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis.
Proteomics: 2006, 6(12);3636-48
[PubMed:16705751] [WorldCat.org] [DOI] (P p)

Aileen Rubio, Xin Jiang, Kit Pogliano
Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa.
J Bacteriol: 2005, 187(14);5000-2
[PubMed:15995216] [WorldCat.org] [DOI] (P p)

Hiroshi Kakeshita, Akihiro Oguro, Reiko Amikura, Kouji Nakamura, Kunio Yamane
Expression of the ftsY gene, encoding a homologue of the alpha subunit of mammalian signal recognition particle receptor, is controlled by different promoters in vegetative and sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 10);2595-2603
[PubMed:11021934] [WorldCat.org] [DOI] (P p)