Difference between revisions of "SrfAB"

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|style="background:#ABCDEF;" align="center"|'''Function''' || antibiotic synthesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || antibiotic synthesis
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03490 srfAB]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 400 kDa, 4.903   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 400 kDa, 4.903   

Revision as of 09:40, 8 August 2012

  • Description: surfactin synthetase / competence

Gene name srfAB
Synonyms comL
Essential no
Product surfactin synthetase / competence
Function antibiotic synthesis
Gene expression levels in SubtiExpress: srfAB
MW, pI 400 kDa, 4.903
Gene length, protein length 10761 bp, 3587 aa
Immediate neighbours srfAA, comS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SrfAB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SrfAB expression.png
























Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, membrane proteins, phosphoproteins

This gene is a member of the following regulons

Abh regulon, CodY regulon, ComA regulon, PerR regulon, Spx regulon

The gene

Basic information

  • Locus tag: BSU03490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylation on Ser-999 AND Ser-2045 PubMed
    • phosphorylated on Arg-1378 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed during hydrogen peroxide stress (PerR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed