Difference between revisions of "AcuC"
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[AcsA]] activity | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[AcsA]] activity | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29710 acuC] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.062 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.062 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[acuB]]'', ''[[motS]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[acuB]]'', ''[[motS]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29710 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29710 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29710 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:acuC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:acuC_context.gif]] | ||
Revision as of 13:37, 13 May 2013
- Description: protein deacetylase for the control of AcsA activity
| Gene name | acuC |
| Synonyms | |
| Essential | no |
| Product | AcsA deacetylase |
| Function | control of AcsA activity |
| Gene expression levels in SubtiExpress: acuC | |
| MW, pI | 42 kDa, 5.062 |
| Gene length, protein length | 1161 bp, 387 aa |
| Immediate neighbours | acuB, motS |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
utilization of specific carbon sources, utilization of lipids, protein modification
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29710
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: deacetylates (and thereby activates) AcsA (together with SrtN) PubMed
- Protein family: histone deacetylase family (according to Swiss-Prot) class I histone deacetylase
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P39067
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jeffrey G Gardner, Jorge C Escalante-Semerena
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase.
J Bacteriol: 2009, 191(6);1749-55
[PubMed:19136592]
[WorldCat.org]
[DOI]
(I p)
Jeffrey G Gardner, Jorge C Escalante-Semerena
Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis.
J Bacteriol: 2008, 190(14);5132-6
[PubMed:18487328]
[WorldCat.org]
[DOI]
(I p)
Jeffrey G Gardner, Frank J Grundy, Tina M Henkin, Jorge C Escalante-Semerena
Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilis.
J Bacteriol: 2006, 188(15);5460-8
[PubMed:16855235]
[WorldCat.org]
[DOI]
(P p)
F J Grundy, A J Turinsky, T M Henkin
Catabolite regulation of Bacillus subtilis acetate and acetoin utilization genes by CcpA.
J Bacteriol: 1994, 176(15);4527-33
[PubMed:7913927]
[WorldCat.org]
[DOI]
(P p)
F J Grundy, D A Waters, T Y Takova, T M Henkin
Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis.
Mol Microbiol: 1993, 10(2);259-71
[PubMed:7934817]
[WorldCat.org]
[DOI]
(P p)
