Difference between revisions of "ClsA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of phospholipids
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of phospholipids
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU36590 clsA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36590 clsA]
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywnF]]'', ''[[mta]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywnF]]'', ''[[mta]]''
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15676&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU36590 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU36590 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU36590 Advanced_DNA]
 
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|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ywnE_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ywnE_context.gif]]

Revision as of 14:03, 13 May 2013

  • Description: cardiolipin synthase, major enzyme

Gene name clsA
Synonyms ywnE
Essential no
Product cardiolipin synthase, major enzyme
Function biosynthesis of phospholipids
Gene expression levels in SubtiExpress: clsA
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 55 kDa, 9.554
Gene length, protein length 1446 bp, 482 aa
Immediate neighbours ywnF, mta
Sequences Protein DNA Advanced_DNA
Genetic context
YwnE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ClsA expression.png




























Categories containing this gene/protein

biosynthesis of lipids, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU36590

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol (according to Swiss-Prot)
  • Protein family: Cardiolipin synthase subfamily (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Letal I Salzberg, John D Helmann
Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition.
J Bacteriol: 2008, 190(23);7797-807
[PubMed:18820022] [WorldCat.org] [DOI] (I p)

Claudia S López, Alejandro F Alice, Horacio Heras, Emilio A Rivas, Carmen Sánchez-Rivas
Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity.
Microbiology (Reading): 2006, 152(Pt 3);605-616
[PubMed:16514141] [WorldCat.org] [DOI] (P p)

Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965] [WorldCat.org] [DOI] (P p)

Fumitaka Kawai, Momoko Shoda, Rie Harashima, Yoshito Sadaie, Hiroshi Hara, Kouji Matsumoto
Cardiolipin domains in Bacillus subtilis marburg membranes.
J Bacteriol: 2004, 186(5);1475-83
[PubMed:14973018] [WorldCat.org] [DOI] (P p)