Difference between revisions of "FadR"

From SubtiWiki
Jump to: navigation, search
Line 56: Line 56:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28550&redirect=T BSU28550]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/lcfA-ysiAB-etfBA.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/lcfA-ysiAB-etfBA.html]
Line 91: Line 92:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28550&redirect=T BSU28550]
  
 
* '''Structure:'''
 
* '''Structure:'''

Revision as of 14:27, 2 April 2014

  • Description: transcriptional repressor (TetR family), regulation of fatty acid degradation

Gene name fadR
Synonyms ysiA
Essential no
Product transcriptional repressor
Function regulation of fatty acid degradation
Gene expression levels in SubtiExpress: fadR
Metabolic function and regulation of this protein in SubtiPathways:
fadR
MW, pI 21 kDa, 6.118
Gene length, protein length 582 bp, 194 aa
Immediate neighbours fadB, lcfA
Sequences Protein DNA DNA_with_flanks
Genetic context
YsiA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FadR expression.png















Categories containing this gene/protein

utilization of lipids, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, FadR regulon

The FadR regulon

The gene

Basic information

  • Locus tag: BSU28550

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471] [WorldCat.org] [DOI] (I p)

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Original publications

Masahiro Fujihashi, Taiga Nakatani, Kazutake Hirooka, Hiroshi Matsuoka, Yasutaro Fujita, Kunio Miki
Structural characterization of a ligand-bound form of Bacillus subtilis FadR involved in the regulation of fatty acid degradation.
Proteins: 2014, 82(7);1301-10
[PubMed:24356978] [WorldCat.org] [DOI] (I p)

Shigeo Tojo, Takenori Satomura, Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Catabolite repression of the Bacillus subtilis FadR regulon, which is involved in fatty acid catabolism.
J Bacteriol: 2011, 193(10);2388-95
[PubMed:21398533] [WorldCat.org] [DOI] (I p)

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)