Difference between revisions of "BceB"

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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
 +
** the activity of the [[BceA]]-[[BceB]] [[ABC transporter]] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[ytpB]]'' mutant {{PubMed|24806199}}
  
 
* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
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=References=
 
=References=
<pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 </pubmed>
+
<pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 24806199</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:50, 11 May 2014

  • Description: ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine

Gene name bceB
Synonyms ytsD
Essential no
Product bacitracin ABC transporter (permease)
Function export of toxic peptides
Gene expression levels in SubtiExpress: bceB
Interactions involving this protein in SubtInteract: BceB
MW, pI 72 kDa, 9.79
Gene length, protein length 1938 bp, 646 aa
Immediate neighbours yttA, bceA
Sequences Protein DNA DNA_with_flanks
Genetic context
YtsD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BceB expression.png















Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

BceR regulon

The gene

Basic information

  • Locus tag: BSU30370

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of bacitracin, plectasin, mersacidin and actagardine (BceR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Anthony W Kingston, Heng Zhao, Gregory M Cook, John D Helmann
Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.
Mol Microbiol: 2014, 93(1);37-49
[PubMed:24806199] [WorldCat.org] [DOI] (I p)

Felix Kallenberg, Sebastian Dintner, Roland Schmitz, Susanne Gebhard
Identification of regions important for resistance and signalling within the antimicrobial peptide transporter BceAB of Bacillus subtilis.
J Bacteriol: 2013, 195(14);3287-97
[PubMed:23687272] [WorldCat.org] [DOI] (I p)

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Jing Ouyang, Xiao-Lin Tian, Jennifer Versey, Alexander Wishart, Yung-Hua Li
The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans.
Antimicrob Agents Chemother: 2010, 54(9);3895-906
[PubMed:20606066] [WorldCat.org] [DOI] (I p)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Remi Bernard, Annick Guiseppi, Marc Chippaux, Maryline Foglino, François Denizot
Resistance to bacitracin in Bacillus subtilis: unexpected requirement of the BceAB ABC transporter in the control of expression of its own structural genes.
J Bacteriol: 2007, 189(23);8636-42
[PubMed:17905982] [WorldCat.org] [DOI] (I p)

Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641] [WorldCat.org] [DOI] (P p)

Remi Bernard, Pascale Joseph, Annick Guiseppi, Marc Chippaux, François Denizot
YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis.
FEMS Microbiol Lett: 2003, 228(1);93-7
[PubMed:14612242] [WorldCat.org] [DOI] (P p)

Reiko Ohki, Giyanto, Kozue Tateno, Waka Masuyama, Shigeki Moriya, Kazuo Kobayashi, Naotake Ogasawara
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Mol Microbiol: 2003, 49(4);1135-44
[PubMed:12890034] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)