Difference between revisions of "Pta"
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' Acetyl-CoA + phosphate = CoA + acetyl phosphate (according to Swiss-Prot) |
* '''Protein family:''' phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot) | * '''Protein family:''' phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot) | ||
Revision as of 16:16, 24 May 2009
- Description: phosphotransacetylase
| Gene name | pta |
| Synonyms | ipa-88d, ywfJ |
| Essential | no |
| Product | phosphotransacetylase |
| Function | overflow metabolism |
| MW, pI | 34 kDa, 4.649 |
| Gene length, protein length | 969 bp, 323 aa |
| Immediate neighbours | cysL, ywfI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Acetyl-CoA + phosphate = CoA + acetyl phosphate (according to Swiss-Prot)
- Protein family: phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylation on (Ser-123 OR Thr-128 OR Ser-129) PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Swiss prot entry: P39646
- KEGG entry: BSU37660
- E.C. number: 2.3.1.8
Additional information
Expression and regulation
- Operon:
- Regulation: expression activated by glucose (2.6 fold) (CcpA) PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
- Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
- Macek et al. (2007) The serine/ threonine/ tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol. Cell. Proteomics 6: 697-707 PubMed
- Presecan-Siedel E, Galinier A, Longin R, Deutscher J, Danchin A, Glaser P, Martin-Verstraete I (1999) The catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis. J Bacteriol 181:6889-6897. PubMed
- Shin BS, Choi SK, Park SH. 1999. Regulation of the Bacillus subtilis phosphotransacetylase gene. J. Biochem. 126:333-339. PubMed
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
