Difference between revisions of "ECF transporter"

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(Important reviews and publications)
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* [[TrpP]]: uptake of tryptophan
 
* [[TrpP]]: uptake of tryptophan
 
* [[YuiG]]: unknown specificity, may also transport biotin
 
* [[YuiG]]: unknown specificity, may also transport biotin
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 +
== The class I ECF transporter for thiamine ==
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* [[ThiU]]: binding protein
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* [[ThiV]]: substrate-specific S component
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* [[ThiW]]: ATP-binding protein (corresponds to A1 + A2)
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* [[ThiX]]: membrane-spanning T protein
  
 
== Important reviews and publications ==
 
== Important reviews and publications ==
 
<pubmed>23584589 , 21135102, 20497229, 18931129 22574898 24362466 27273632</pubmed>
 
<pubmed>23584589 , 21135102, 20497229, 18931129 22574898 24362466 27273632</pubmed>

Revision as of 14:56, 4 May 2018

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transport proteins


ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins. In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.

The general components of the ECF transporters

  • ybxA ATP-binding A1 protein (EcfA1)
  • ybaE ATP-binding A2 protein (EcfA2)
  • ybaF membrane-spanning T protein (EcfT)

The substrate-specific S components of the ECF transporters

  • RibU: uptake of riboflavin
  • ThiT: uptake of thiamine
  • YhfU: uptake of biotin
  • TrpP: uptake of tryptophan
  • YuiG: unknown specificity, may also transport biotin

The class I ECF transporter for thiamine

  • ThiU: binding protein
  • ThiV: substrate-specific S component
  • ThiW: ATP-binding protein (corresponds to A1 + A2)
  • ThiX: membrane-spanning T protein

Important reviews and publications