FadN

From SubtiWiki
Revision as of 10:00, 25 June 2009 by Sroppel (talk | contribs)
Jump to: navigation, search
  • Description: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)

Gene name fadN
Synonyms yusL
Essential no
Product 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
Function fatty acid degradation
MW, pI 89 kDa, 6.53
Gene length, protein length 2445 bp, 815 aa
Immediate neighbours fadA, fadM
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YusL context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU32840

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH (according to Swiss-Prot)
  • Protein family: 3-hydroxyacyl-CoA dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation: repressed by glucose (4.5-fold) PubMed
    • repressed in the absence of long-chain fatty acids (FadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References