LipA

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  • Description: trigger enzyme: lipoic acid synthase and regulator of comE operon expression

Gene name lipA
Synonyms yutB
Essential Yes PubMed
Product trigger enzyme: lipoic acid synthase
Function lipid metabolism, required for the synthesis of branched-chain amino acids
MW, pI 33 kDa, 8.251
Gene length, protein length 894 bp, 298 aa
Immediate neighbours yutC, lytH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
LipA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU32330

Phenotypes of a mutant

reduced transformation efficiency PubMed, strong inhibition of growth on minimal media PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Categories containing this gene/protein

biosynthesis of cofactors, trigger enzyme

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot) Triacylglycerol + H2O = diacylglycerol + a carboxylate (according to Swiss-Prot) required for comEA transcription PubMed
  • Protein family: Lipoyl synthase family (according to Swiss-Prot) AB hydrolase superfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: extracellular (signal peptide) PubMed

Database entries

  • Structure:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References