VmlR

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  • Description: ABC transporter (ATP-binding protein), efflux of antibiotics (virginiamycin M, lincomycin)

Gene name vmlR
Synonyms expZ
Essential no
Product antibiotic efflux ABC transporter (ATP-binding protein)
Function efflux of antibiotics (virginiamycin M, lincomycin)
MW, pI 62 kDa, 6.727
Gene length, protein length 1641 bp, 547 aa
Immediate neighbours ydgE, ydgF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ExpZ context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics

This gene is a member of the following regulons

RNA switch/ other

The gene

Basic information

  • Locus tag: BSU05610

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by virginiamycin M or lincomycin PubMed
  • Regulatory mechanism: transcriptional antitermination, details are unknown PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reiko Ohki, Kozue Tateno, Teruaki Takizawa, Toshiko Aiso, Makiko Murata
Transcriptional termination control of a novel ABC transporter gene involved in antibiotic resistance in Bacillus subtilis.
J Bacteriol: 2005, 187(17);5946-54
[PubMed:16109936] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)