TuaA/1

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  • Description: lipid carrier sugar transferase

Gene name tuaA
Synonyms yvhA
Essential no
Product lipid carrier sugar transferase
Function biosynthesis of teichuronic acid
MW, pI 20 kDa, 10.361
Gene length, protein length 537 bp, 179 aa
Immediate neighbours tuaB, lytC
Gene sequence (+200bp) Protein sequence
Genetic context
TuaA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

  • Locus tag: BSU35610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-N-acetyl-D-galactosamine + undecaprenyl phosphate = UMP + N-acetyl-alpha-D-galactosaminyldiphospho-undecaprenol (according to Swiss-Prot)
  • Protein family: bacterial sugar transferase family (according to Swiss-Prot)
  • Paralogous protein(s): EpsL

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions of phosphate limitation (PhoP) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Maryam Lahooti, Colin R Harwood
Transcriptional analysis of the Bacillus subtilis teichuronic acid operon.
Microbiology (Reading): 1999, 145 ( Pt 12);3409-3417
[PubMed:10627039] [WorldCat.org] [DOI] (P p)

B Soldo, V Lazarevic, M Pagni, D Karamata
Teichuronic acid operon of Bacillus subtilis 168.
Mol Microbiol: 1999, 31(3);795-805
[PubMed:10048024] [WorldCat.org] [DOI] (P p)

Y Qi, F M Hulett
Role of Pho-P in transcriptional regulation of genes involved in cell wall anionic polymer biosynthesis in Bacillus subtilis.
J Bacteriol: 1998, 180(15);4007-10
[PubMed:9683503] [WorldCat.org] [DOI] (P p)

Wei Liu, F Marion Hulett
Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site.
Microbiology (Reading): 1998, 144 ( Pt 5);1443-1450
[PubMed:9611818] [WorldCat.org] [DOI] (P p)