ScoC

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  • Description: transcriptional repressor of genes expressed in the transition phase

Gene name scoC
Synonyms hpr, catA
Essential no
Product transcriptional repressor (MarR family)
Function transition state regulator
Regulation of this protein in SubtiPathways:
Biofilm, Alternative nitrogen sources
MW, pI 23 kDa, 5.188
Gene length, protein length 609 bp, 203 aa
Immediate neighbours yhaI, yhaH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Hpr context.gif
This image was kindly provided by SubtiList








Categories containing this gene/protein

transcription factors and their control, transition state regulators

This gene is a member of the following regulons

AbrB regulon, SalA regulon, SenS regulon

The gene

Basic information

  • Locus tag: BSU09990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes controlled by ScoC

repressed: aprE, bacA-bacB-bacC-bacD-bacE-bacF PubMed, hag PubMed, flgM PubMed

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed upon transition into the stationary phase (AbrB) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Bindiya Kaushal, Salbi Paul, F Marion Hulett
Direct regulation of Bacillus subtilis phoPR transcription by transition state regulator ScoC.
J Bacteriol: 2010, 192(12);3103-13
[PubMed:20382764] [WorldCat.org] [DOI] (I p)

Prashant Kodgire, K Krishnamurthy Rao
A dual mode of regulation of flgM by ScoC in Bacillus subtilis.
Can J Microbiol: 2009, 55(8);983-9
[PubMed:19898538] [WorldCat.org] [DOI] (I p)

Takashi Inaoka, Guojun Wang, Kozo Ochi
ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
J Bacteriol: 2009, 191(23);7367-71
[PubMed:19801406] [WorldCat.org] [DOI] (I p)

Prashant Kodgire, K Krishnamurthy Rao
hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC.
Microbiology (Reading): 2009, 155(Pt 1);142-149
[PubMed:19118355] [WorldCat.org] [DOI] (P p)

Prashant Kodgire, Madhulika Dixit, K Krishnamurthy Rao
ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis.
J Bacteriol: 2006, 188(17);6425-8
[PubMed:16923912] [WorldCat.org] [DOI] (P p)

Eiji Kawachi, Sadanobu Abe, Teruo Tanaka
Inhibition of Bacillus subtilis scoC expression by multicopy senS.
J Bacteriol: 2005, 187(24);8526-30
[PubMed:16321961] [WorldCat.org] [DOI] (P p)

Mitsuo Ogura, Atsushi Matsuzawa, Hirofumi Yoshikawa, Teruo Tanaka
Bacillus subtilis SalA (YbaL) negatively regulates expression of scoC, which encodes the repressor for the alkaline exoprotease gene, aprE.
J Bacteriol: 2004, 186(10);3056-64
[PubMed:15126467] [WorldCat.org] [DOI] (P p)

Alejandro Sánchez, Jorge Olmos
Bacillus subtilis transcriptional regulators interaction.
Biotechnol Lett: 2004, 26(5);403-7
[PubMed:15104138] [WorldCat.org] [DOI] (P p)

Sasha H Shafikhani, Esperanza Núñez, Terrance Leighton
ScoC mediates catabolite repression of sporulation in Bacillus subtilis.
Curr Microbiol: 2003, 47(4);327-36
[PubMed:14629015] [WorldCat.org] [DOI] (P p)

A Koide, M Perego, J A Hoch
ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis.
J Bacteriol: 1999, 181(13);4114-7
[PubMed:10383984] [WorldCat.org] [DOI] (P p)

P T Kallio, J E Fagelson, J A Hoch, M A Strauch
The transition state regulator Hpr of Bacillus subtilis is a DNA-binding protein.
J Biol Chem: 1991, 266(20);13411-7
[PubMed:1906467] [WorldCat.org] (P p)

B C Dowds, J A Hoch
Regulation of the oxidative stress response by the hpr gene in Bacillus subtilis.
J Gen Microbiol: 1991, 137(5);1121-5
[PubMed:1907636] [WorldCat.org] [DOI] (P p)

M A Strauch, G B Spiegelman, M Perego, W C Johnson, D Burbulys, J A Hoch
The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein.
EMBO J: 1989, 8(5);1615-21
[PubMed:2504584] [WorldCat.org] [DOI] (P p)

M Perego, J A Hoch
Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis.
J Bacteriol: 1988, 170(6);2560-7
[PubMed:3131303] [WorldCat.org] [DOI] (P p)