PabB

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  • Description: para-aminobenzoate synthase (subunit A)

Gene name pabB
Synonyms pab
Essential no
Product para-aminobenzoate synthase (subunit A)
Function biosynthesis of folate
Gene expression levels in SubtiExpress: pabB
Interactions involving this protein in SubtInteract: PabB
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp, Folate
MW, pI 53 kDa, 5.234
Gene length, protein length 1410 bp, 470 aa
Immediate neighbours cysK, pabA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PabB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PabB expression.png




























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00740

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate (according to Swiss-Prot)
  • Protein family: anthranilate synthase component I family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Antoine de Saizieu, Pierre Vankan, Cassandra Vockler, Adolphus P G M van Loon
The trp RNA-binding attenuation protein (TRAP) regulates the steady-state levels of transcripts of the Bacillus subtilis folate operon.
Microbiology (Reading): 1997, 143 ( Pt 3);979-989
[PubMed:9084182] [WorldCat.org] [DOI] (P p)