PatB

• Description: cystathione-beta-lyase
  
  

Gene name	patB
Synonyms
Essential	no
Product	cystathione-beta-lyase
Function	biosynthesis of methionine
Gene expression levels in SubtiExpress: patB
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	42 kDa, 5.439
Gene length, protein length	1161 bp, 387 aa
Immediate neighbours	yugE, kinB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU31440

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-cystathionine + H₂O = L-homocysteine + NH₃ + pyruvate (according to Swiss-Prot)

• Protein family: MalY/patB cystathionine beta-lyase subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3T32 (from B. anthracis, 46% identity, 75% similarity)

• UniProt: Q08432

• KEGG entry: [3]

• E.C. number: 4.4.1.8

Expression and regulation

• Operon: patB PubMed

• Expression browser: patB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A952 ( patB::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: