CysL

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  • Description: transcriptional activator of the cysJ-cysI operon

Gene name cysL
Synonyms ywfK, ipa-89d
Essential no
Product transcriptional regulator (LysR family)
Function regulation of cysteine biosynthesis
Gene expression levels in SubtiExpress: cysL
Metabolic function and regulation of this protein in SubtiPathways:
Cys, Met & Sulfate assimilation
MW, pI 34 kDa, 6.963
Gene length, protein length 897 bp, 299 aa
Immediate neighbours lipL, pta
Sequences Protein DNA Advanced_DNA
Genetic context
YwfK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CysL expression.png




























Categories containing this gene/protein

sulfur metabolism, transcription factors and their control

This gene is a member of the following regulons

CysL regulon

The CysL regulon:

The gene

Basic information

  • Locus tag: BSU37650

Phenotypes of a mutant

  • unable to grow with sulfate or sulfite as the only sulfur source PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by sulfate, sulfite, and thiosulfate (CysL) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Isabelle Guillouard, Sandrine Auger, Marie-Françoise Hullo, Farid Chetouani, Antoine Danchin, Isabelle Martin-Verstraete
Identification of Bacillus subtilis CysL, a regulator of the cysJI operon, which encodes sulfite reductase.
J Bacteriol: 2002, 184(17);4681-9
[PubMed:12169591] [WorldCat.org] [DOI] (P p)