YodB

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Gene name yodB
Synonyms
Essential no
Product MarR/DUF24 family transcription repressor
Function regulation of quinone and diamide detoxification
Gene expression levels in SubtiExpress: yodB
MW, pI 12 kDa, 4.737
Gene length, protein length 336 bp, 112 aa
Immediate neighbours yodA, yodC
Sequences Protein DNA DNA_with_flanks
Genetic context
YodB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YodB expression.png















Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

YodB regulon

The YodB regulon:

The gene

Basic information

  • Locus tag: BSU19540

Phenotypes of a mutant

  • increased resistance to catechol, quinones and diamide PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s): CatR

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamide
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • subject to autorepression PubMed
  • Regulatory mechanism:
    • YodB: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Your additional remarks

References

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)


Original Publications