SecE

• Description: preprotein translocase subunit
  
  

Gene name	secE
Synonyms
Essential	yes PubMed
Product	preprotein translocase subunit
Function	protein secretion
Gene expression levels in SubtiExpress: secE
Interactions involving this protein in SubtInteract: SecE
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	6 kDa, 10.47
Gene length, protein length	177 bp, 59 aa
Immediate neighbours	rpmGB, nusG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU01000

Phenotypes of a mutant

essential PubMed PubMed

Database entries

• BsubCyc: BSU01000

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: secE/SEC61-gamma family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: transmembrane protein with a single TM domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (SecY-SecE-SecG)2-SecA2 PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU01000

• Structure: 3DL8 (structure of the (SecY-SecE-SecG)-SecA complex) PubMed

• UniProt: Q06799

• KEGG entry: [2]

• E.C. number:

Additional information

B. subtilis secE complements the secretion phenotype of a cold sensitive E. coli secE mutant.

Expression and regulation

• Operon:

• Expression browser: secE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

S M Jeong, H Yoshikawa, H Takahashi
Isolation and characterization of the secE homologue gene of Bacillus subtilis.
Mol Microbiol: 1993, 10(1);133-42
[PubMed:7968510] [WorldCat.org] [DOI] (P p)