YkgB

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  • Description: 6-phosphogluconolactonase, general stress protein

Gene name ykgB
Synonyms
Essential no
Product 6-phosphogluconolactonase
Function pentose phosphate pathway
Gene expression levels in SubtiExpress: ykgB
MW, pI 38 kDa, 5.154
Gene length, protein length 1047 bp, 349 aa
Immediate neighbours ykfD, ykgA
Sequences Protein DNA DNA_with_flanks
Genetic context
YkgB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YkgB expression.png















Categories containing this gene/protein

general stress proteins (controlled by SigB), carbon core metabolism

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU13010

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • 6-phosphogluconolactone --> 6-phosphogluconate (pentose phosphate pathway) PubMed
  • Protein family: cycloisomerase 2 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:
  • FLAG-tag construct: GP1402 (spc, based on pGP1331), available in the Stülke lab

Labs working on this gene/protein

Your additional remarks

References

Germán Plata, Tobias Fuhrer, Tzu-Lin Hsiao, Uwe Sauer, Dennis Vitkup
Global probabilistic annotation of metabolic networks enables enzyme discovery.
Nat Chem Biol: 2012, 8(10);848-54
[PubMed:22960854] [WorldCat.org] [DOI] (I p)

Lynn C Thomason, Donald L Court, Atin R Datta, Rita Khanna, Judah L Rosner
Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase.
J Bacteriol: 2004, 186(24);8248-53
[PubMed:15576773] [WorldCat.org] [DOI] (P p)

A Petersohn, J Bernhardt, U Gerth, D Höper, T Koburger, U Völker, M Hecker
Identification of sigma(B)-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization.
J Bacteriol: 1999, 181(18);5718-24
[PubMed:10482513] [WorldCat.org] [DOI] (P p)