SecE

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  • Description: preprotein translocase subunit

Gene name secE
Synonyms
Essential yes PubMed
Product preprotein translocase subunit
Function protein secretion
Gene expression levels in SubtiExpress: secE
Interactions involving this protein in SubtInteract: SecE
Metabolic function and regulation of this protein in SubtiPathways:
SecE
MW, pI 6 kDa, 10.47
Gene length, protein length 177 bp, 59 aa
Immediate neighbours rpmGB, nusG
Sequences Protein DNA DNA_with_flanks
Genetic context
SecE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SecE expression.png
























Categories containing this gene/protein

protein secretion, essential genes, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU01000

Phenotypes of a mutant

essential PubMed PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: secE/SEC61-gamma family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: transmembrane protein with a single TM domain
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

B. subtilis secE complements the secretion phenotype of a cold sensitive E. coli secE mutant.

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jochen Zimmer, Yunsun Nam, Tom A Rapoport
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature: 2008, 455(7215);936-43
[PubMed:18923516] [WorldCat.org] [DOI] (I p)

S M Jeong, H Yoshikawa, H Takahashi
Isolation and characterization of the secE homologue gene of Bacillus subtilis.
Mol Microbiol: 1993, 10(1);133-42
[PubMed:7968510] [WorldCat.org] [DOI] (P p)