ComGC

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  • Description: DNA uptake, major component of the pseudopilus

Gene name comGC
Synonyms
Essential no
Product major pseudopilin
Function genetic competence
Gene expression levels in SubtiExpress: comGC
Interactions involving this protein in SubtInteract: ComGC
Metabolic function and regulation of this protein in SubtiPathways:
ComGC
MW, pI 10 kDa, 6.325
Gene length, protein length 294 bp, 98 aa
Immediate neighbours comGD, comGB
Sequences Protein DNA DNA_with_flanks
Genetic context
ComGC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComGC expression.png
























Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU24710

Phenotypes of a mutant

  • knockout has complete loss of transformation competence

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: comGC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • cell surface PubMed
    • localizes to the cell membrane and the cytoplasm PubMed
    • localizes to one single cell pole in the majority of the cells PubMed

= Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)

Original publications