SirA

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  • Description: sporulation protein, inhibits DNA replication

Gene name sirA
Synonyms yneE, yoxF
Essential no
Product inhibitor of DNA replication
Function control of chromosome copy number
MW, pI 17 kDa, 7.353
Gene length, protein length 444 bp, 148 aa
Immediate neighbours tkt, yneF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YneE context.gif
This image was kindly provided by SubtiList



The gene

yneE was renamed to sirA.

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.

References

Lilah Rahn-Lee, Boris Gorbatyuk, Ole Skovgaard, Richard Losick
The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis.
J Bacteriol: 2009, 191(11);3736-9
[PubMed:19329632] [WorldCat.org] [DOI] (I p)