SigI

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  • Description: RNA polymerase sigma factor SigI

Gene name sigI
Synonyms ykoZ
Essential no
Product RNA polymerase sigma factor SigI
Function control of a class of heat shock genes
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 29 kDa, 8.306
Gene length, protein length 753 bp, 251 aa
Immediate neighbours ykoY, rsgI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SigI context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU13450

Phenotypes of a mutant

temperature-sensitive growth on agar plates PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Members of the SigI regulon

gsiB PubMed, mreBH, bcrC PubMed

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by heat PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Kathrin Schirner, Jeff Errington
The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis.
J Bacteriol: 2009, 191(5);1404-13
[PubMed:19114499] [WorldCat.org] [DOI] (I p)

Chi-Ling Tseng, Gwo-Chyuan Shaw
Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis.
J Bacteriol: 2008, 190(5);1561-7
[PubMed:18156261] [WorldCat.org] [DOI] (I p)

Kei Asai, Takafumi Ootsuji, Kazue Obata, Takashi Matsumoto, Yasutaro Fujita, Yoshito Sadaie
Regulatory role of RsgI in sigI expression in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 1);92-101
[PubMed:17185538] [WorldCat.org] [DOI] (P p)

U Zuber, K Drzewiecki, M Hecker
Putative sigma factor SigI (YkoZ) of Bacillus subtilis is induced by heat shock.
J Bacteriol: 2001, 183(4);1472-5
[PubMed:11157964] [WorldCat.org] [DOI] (P p)