PfkA

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  • Description: is the main controling enzyme of the glycolysis. Phosphorylates fructose 6-phosphate to fructose 1,3-bisphosphate

Gene name pfkA
Synonyms pfk
Essential yes
Product 6-phosphofructokinase
Function phosphorylation of fructose 6-phosphat
MW, pI 34,1 kDa, 6.14
Gene length, protein length 957 bp, 319 amino acids
Immediate neighbours accA, pyk
Gene sequence (+200bp) Protein sequence
Genetic context
File:GenE context.gif












The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
  • Protein family: phosphofructokinase family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • 3 x nucleotide binding domain (ATP) (21–25), (154–158), (171–187)
  • Modification:
  • Cofactor(s): ATP
  • Effectors of protein activity:
  • Interactions: Pyk-PfkA
  • Localization: Cytoplasm PubMed

Database entries

  • Structure: Geobacillus stearothermophilus NCBI, Mutan, complex with Fructose-6-phosphate Geobacillus stearothermophilus NCBI
  • Swiss prot entry: [3]
  • KEGG entry: [4]
  • E.C. number: [5]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: induced by Glucose
  • Regulatory mechanism:
  • Additional information:

Biological materials

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed