Difference between revisions of "AdhR"

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= Categories containing this gene/protein =
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{{SubtiWiki category|[[transcription factors and their control]]}},
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{{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
 
=The protein=
 
=The protein=
  

Revision as of 14:47, 30 November 2010

  • Description: transcriptional activator of adhA-yraA

Gene name adhR
Synonyms yraB
Essential no
Product transcriptional activator (MerR family)
Function regulation of the protective response to formaldehyde
MW, pI 16 kDa, 9.637
Gene length, protein length 420 bp, 140 aa
Immediate neighbours yraD, adhA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YraB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU27000

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: activity probably controlled via thiol-(S)-alkylation in Cys-52 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: spore wall (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)