DnaK

• Description: class I heat-shock protein (molecular chaperone)
  
  

Gene name	dnaK
Synonyms
Essential	no
Product	class I heat-shock protein (molecular chaperone)
Function	protein quality control
MW, pI	65 kDa, 4.571
Gene length, protein length	1833 bp, 611 aa
Immediate neighbours	surC, grpE
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hrcA-grpE-dnaK-dnaJ PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by heat shock PubMed

• Regulatory mechanism: repressed at normal temperature by HrcA

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage

References

1. Wetzstein, M., U. Völker, J. Dedio, S. Löbau, U. Zuber, M. Schiesswohl, C. Herget, M. Hecker, and W. Schumann. 1992. Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis. J. Bacteriol. 174:3300-3310. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed