Elongasome

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Revision as of 18:27, 13 July 2011 by Jstuelk (talk | contribs) (Complex members)
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A protein complex that catalyzes peptidoglycan biosynthesis and is thereby involved in maintaining cell shape

Complex members

  • cell wall biosynthetic enzymes at the outer side of the membrane: penicillin-binding proteins (PbpA, PbpH)
  • transmembrane proteins: MreC, MreD, RodA, RodZ, they couple the cytosolic actin-like proteins to the extracellular peptidoglycan-synthesizing machinery
  • actin-like proteins at the inner surface of the membrane: MreB, MreBH, Mbl, the polymers control/restrict the mobility of the cell wall elongation enzyme complex

Related pages

Labs working on the complex

Important publications

Ethan C Garner, Remi Bernard, Wenqin Wang, Xiaowei Zhuang, David Z Rudner, Tim Mitchison
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis.
Science: 2011, 333(6039);222-5
[PubMed:21636745] [WorldCat.org] [DOI] (I p)

Julia Domínguez-Escobar, Arnaud Chastanet, Alvaro H Crevenna, Vincent Fromion, Roland Wedlich-Söldner, Rut Carballido-López
Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria.
Science: 2011, 333(6039);225-8
[PubMed:21636744] [WorldCat.org] [DOI] (I p)

  • A comment on these papers:

Andrew Jermy
Bacterial physiology: MreB takes a back seat.
Nat Rev Microbiol: 2011, 9(8);560-1
[PubMed:21725336] [WorldCat.org] [DOI] (I e)


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