GltC

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Revision as of 18:31, 10 December 2008 by Jstuelk (talk | contribs) (Extended information on the protein)
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  • Synonyms:
  • Description: Transcriptional activator of the gltAB operon. Activates expression of the operon in the absence of arginine.

The gene

Basic information

  • Coordinates:
  • Gene length:

Database entries

  • DBTBS entry:

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activation of the gltAB operon
  • Protein family: LysR-type transcription regulator
  • Paralogous protein(s): none, but there are 19 members of the LysR family in B. subtilis

Database entries

  • Structure
  • Swiss prot entry
  • KEGG entry

Extended information on the protein

  • Kinetic information
  • Domains DNA-binding helix-turn-helix motif: AA 18 ... 37
  • Modification
  • Effectors of protein activity:2-oxoglutarate
  • Interactions:
    • GltC-RocG, This interaction takes place in the presence of glutamate. It prevents the transcription activation of the gltAB operon. Note that RocG expression is strongly regulated. <ref>Commichau et al.(2007)</ref>
  • Localization

Expression and Regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:

Biological Materials

  • Mutant x
  • Expression vector x
  • lacZ fusion
  • GFP fusion
  • Antibody x


Phenotypes of a Mutant

Additional remarks

  • Labs working on this gene/protein:

Linc Sonenshein, Tufts University, Boston, MA, USA [1]

Jörg Stülke, University of Göttingen, Germany [2]

References