Difference between revisions of "Glutamate metabolism"

From SubtiWiki
Jump to: navigation, search
(Created page with "== Reviews == <pubmed> 18086213 16458044 </pubmed> ==Regulation of glutamate synthase expression== <pubmed> 14523131 17183217 17608797 20630473 </pubmed> ==Regulatory protein-p...")
 
(Proteins involved in glutamate metabolism)
 
(27 intermediate revisions by 2 users not shown)
Line 1: Line 1:
== Reviews ==
+
= Proteins involved in glutamate metabolism =
<pubmed> 18086213 16458044 </pubmed>
 
  
==Regulation of glutamate synthase expression==
+
=== Transport systems ===
<pubmed> 14523131 17183217 17608797 20630473 </pubmed>
+
* Ammonium uptake: [[NrgA|AmtB]]
 +
* Glutamine uptake: [[GlnT]], [[GlnQ]]-([[GlnM]]-[[GlnP]])-[[GlnH]]
 +
* Glutamate uptake: [[YbeC]], [[GltT]]
  
==Regulatory protein-protein interactions in nitrogen regulation==
+
=== Metabolic enzymes===
<pubmed> 17001076 17608797 </pubmed>
+
* Glutamine synthetase: [[GlnA]]
 +
* Glutamate synthase: [[GltA]], [[GltB]]
 +
* Glutamate dehydrogenases: [[GudB]], [[RocG]]
  
== Glutamate homeostasis by  the acquisition of mutations ==
+
=== Regulators ===
<pubmed> 18326565 21219666 22178973 </pubmed>
+
* Key transcriptional regulators of nitrogen metabolism: [[GlnR]], [[GltC]], [[TnrA]]
 +
* Additional transcriptional regulators: [[AhrC]], [[RocR]], [[CcpA]], [[Fur]]
 +
* Control of ammonium uptake: [[NrgB|GlnK]]
  
== Additional stuff ==
+
= Relevant ''Subti''Wiki pages =  
<pubmed> 14600241 20933603 </pubmed>
+
* [[Biosynthesis/ acquisition of amino acids]]
 +
* [[Utilization of amino acids]]
 +
* [[TnrA regulon]]
 +
* [[GlnR regulon]]
 +
* [[GltC regulon]]
 +
* [[Trigger enzymes]]
  
== Methods ==
+
= Glutamate metabolism in [[SubtiPathways]]: [http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate] =
<pubmed> 17994626 </pubmed>
+
 
 +
= Additional websites =
 +
* [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34383&submit.x=22&submit.y=9 transcriptome analysis of a ''[[rocG]] [[gudB]]'' mutant vs. wild type]
 +
 
 +
= Labs studying glutamate metabolism=
 +
 
 +
* [[Fabian Commichau]], Göttingen, Germany
 +
* [[Susan Fisher]], Boston
 +
* [[Linc Sonenshein]], Boston
 +
* [[Jörg Stülke]], Göttingen
 +
 
 +
= Important publications =
 +
==Reviews==
 +
<pubmed>18086213,17982469,16458044,10231480 22625175</pubmed>
 +
== Important original publications ==
 +
<pubmed>23811508 </pubmed>

Latest revision as of 10:44, 6 May 2021

Proteins involved in glutamate metabolism

Transport systems

Metabolic enzymes

Regulators

  • Key transcriptional regulators of nitrogen metabolism: GlnR, GltC, TnrA
  • Additional transcriptional regulators: AhrC, RocR, CcpA, Fur
  • Control of ammonium uptake: GlnK

Relevant SubtiWiki pages

Glutamate metabolism in SubtiPathways: Ammonium/ glutamate

Additional websites

Labs studying glutamate metabolism

Important publications

Reviews

Katrin Gunka, Fabian M Commichau
Control of glutamate homeostasis in Bacillus subtilis: a complex interplay between ammonium assimilation, glutamate biosynthesis and degradation.
Mol Microbiol: 2012, 85(2);213-24
[PubMed:22625175] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Jörg Stülke
Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression.
Mol Microbiol: 2008, 67(4);692-702
[PubMed:18086213] [WorldCat.org] [DOI] (P p)

Abraham L Sonenshein
Control of key metabolic intersections in Bacillus subtilis.
Nat Rev Microbiol: 2007, 5(12);917-27
[PubMed:17982469] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Karl Forchhammer, Jörg Stülke
Regulatory links between carbon and nitrogen metabolism.
Curr Opin Microbiol: 2006, 9(2);167-72
[PubMed:16458044] [WorldCat.org] [DOI] (P p)

S H Fisher
Regulation of nitrogen metabolism in Bacillus subtilis: vive la différence!
Mol Microbiol: 1999, 32(2);223-32
[PubMed:10231480] [WorldCat.org] [DOI] (P p)

Important original publications

Anne Krog, Tonje Marita Bjerkan Heggeset, Trond Erling Ellingsen, Trygve Brautaset
Functional characterization of key enzymes involved in L-glutamate synthesis and degradation in the thermotolerant and methylotrophic bacterium Bacillus methanolicus.
Appl Environ Microbiol: 2013, 79(17);5321-8
[PubMed:23811508] [WorldCat.org] [DOI] (I p)