Difference between revisions of "Pcp"

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* '''Structure:'''
 
* '''Structure:'''
  
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P28618 P28618]
+
* '''UniProt:''' [http://www.uniprot.org/uniprot/P28618 P28618]
  
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU02650]
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU02650]

Revision as of 10:28, 20 July 2009

  • Description: pyrrolidone-carboxylate peptidase

Gene name pcp
Synonyms
Essential no
Product pyrrolidone-carboxylate peptidase
Function removal of the N-terminal pyroglutamyl group from peptides
MW, pI 23 kDa, 6.418
Gene length, protein length 645 bp, 215 aa
Immediate neighbours tatCD, ycbU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Pcp context.gif
This image was kindly provided by SubtiList





The gene

Basic information

  • Locus tag: BSU02650

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to Swiss-Prot)
  • Protein family: peptidase C15 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

T Gonzalès, A Awadé, C Besson, J Robert-Baudouy
Purification and characterization of recombinant pyrrolidone carboxyl peptidase of Bacillus subtilis.
J Chromatogr: 1992, 584(1);101-7
[PubMed:1362573] [DOI] (P p)

A Awadé, P Cleuziat, T Gonzalès, J Robert-Baudouy
Characterization of the pcp gene encoding the pyrrolidone carboxyl peptidase of Bacillus subtilis.
FEBS Lett: 1992, 305(1);67-73
[PubMed:1353026] [WorldCat.org] [DOI] (P p)