Difference between revisions of "Pcp"
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|style="background:#ABCDEF;" align="center"|'''Function''' || removal of the N-terminal pyroglutamyl group from peptides | |style="background:#ABCDEF;" align="center"|'''Function''' || removal of the N-terminal pyroglutamyl group from peptides | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 23 kDa, 6.418 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 23 kDa, 6.418 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:pcp_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:pcp_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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* '''Operon:''' | * '''Operon:''' | ||
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=Biological materials = | =Biological materials = | ||
Revision as of 10:38, 7 August 2012
- Description: pyrrolidone-carboxylate peptidase
| Gene name | pcp |
| Synonyms | |
| Essential | no |
| Product | pyrrolidone-carboxylate peptidase |
| Function | removal of the N-terminal pyroglutamyl group from peptides |
| MW, pI | 23 kDa, 6.418 |
| Gene length, protein length | 645 bp, 215 aa |
| Immediate neighbours | tatCD, ycbU |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU02650
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to Swiss-Prot)
- Protein family: peptidase C15 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P28618
- KEGG entry: [2]
- E.C. number: 3.4.11.8
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
T Gonzalès, A Awadé, C Besson, J Robert-Baudouy
Purification and characterization of recombinant pyrrolidone carboxyl peptidase of Bacillus subtilis.
J Chromatogr: 1992, 584(1);101-7
[PubMed:1362573]
[DOI]
(P p)
A Awadé, P Cleuziat, T Gonzalès, J Robert-Baudouy
Characterization of the pcp gene encoding the pyrrolidone carboxyl peptidase of Bacillus subtilis.
FEBS Lett: 1992, 305(1);67-73
[PubMed:1353026]
[WorldCat.org]
[DOI]
(P p)
