Difference between revisions of "Pcp"
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || removal of the N-terminal pyroglutamyl group from peptides | |style="background:#ABCDEF;" align="center"|'''Function''' || removal of the N-terminal pyroglutamyl group from peptides | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU02650 pcp] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 23 kDa, 6.418 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 23 kDa, 6.418 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tatCD]]'', ''[[ycbU]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tatCD]]'', ''[[ycbU]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU02650 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU02650 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU02650 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:pcp_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:pcp_context.gif]] | ||
Revision as of 12:04, 13 May 2013
- Description: pyrrolidone-carboxylate peptidase
| Gene name | pcp |
| Synonyms | |
| Essential | no |
| Product | pyrrolidone-carboxylate peptidase |
| Function | removal of the N-terminal pyroglutamyl group from peptides |
| Gene expression levels in SubtiExpress: pcp | |
| MW, pI | 23 kDa, 6.418 |
| Gene length, protein length | 645 bp, 215 aa |
| Immediate neighbours | tatCD, ycbU |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU02650
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to Swiss-Prot)
- Protein family: peptidase C15 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P28618
- KEGG entry: [2]
- E.C. number: 3.4.11.8
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
T Gonzalès, A Awadé, C Besson, J Robert-Baudouy
Purification and characterization of recombinant pyrrolidone carboxyl peptidase of Bacillus subtilis.
J Chromatogr: 1992, 584(1);101-7
[PubMed:1362573]
[DOI]
(P p)
A Awadé, P Cleuziat, T Gonzalès, J Robert-Baudouy
Characterization of the pcp gene encoding the pyrrolidone carboxyl peptidase of Bacillus subtilis.
FEBS Lett: 1992, 305(1);67-73
[PubMed:1353026]
[WorldCat.org]
[DOI]
(P p)
