Pcp

• Description: pyrrolidone-carboxylate peptidase
  
  

Gene name	pcp
Synonyms
Essential	no
Product	pyrrolidone-carboxylate peptidase
Function	removal of the N-terminal pyroglutamyl group from peptides
Gene expression levels in SubtiExpress: pcp
MW, pI	23 kDa, 6.418
Gene length, protein length	645 bp, 215 aa
Immediate neighbours	tatCD, ycbU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification

The gene

Basic information

• Locus tag: BSU02650

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to Swiss-Prot)

• Protein family: peptidase C15 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P28618

• KEGG entry: [2]

• E.C. number: 3.4.11.8

Expression and regulation

• Operon:

• Expression browser: pcp PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

T Gonzalès, A Awadé, C Besson, J Robert-Baudouy
Purification and characterization of recombinant pyrrolidone carboxyl peptidase of Bacillus subtilis.
J Chromatogr: 1992, 584(1);101-7
[PubMed:1362573] [DOI] (P p)

A Awadé, P Cleuziat, T Gonzalès, J Robert-Baudouy
Characterization of the pcp gene encoding the pyrrolidone carboxyl peptidase of Bacillus subtilis.
FEBS Lett: 1992, 305(1);67-73
[PubMed:1353026] [WorldCat.org] [DOI] (P p)