Difference between revisions of "Sr1"

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* '''Structure:'''
 
* '''Structure:'''
  
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* '''UniProt:''' [http://www.uniprot.org/uniprot/C0H410 C0H410]
  
 
* '''KEGG entry:'''
 
* '''KEGG entry:'''

Revision as of 07:51, 22 July 2009

  • Description: small regulatory RNA controlling AhrC expression

Gene name sr1
Synonyms ykzW
Essential no
Product small regulatory RNA/ regulatory peptide
Function control of arginine metabolism
MW, pI 4.4 kDa, 3.89
Gene length, protein length 205 bp (RNA), 120 bp (ORF), 39 aa
Immediate neighbours slp, speA
Gene sequence
Genetic context
Sr1 context.gif





The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry

Additional information

Located between the slp and speA genes.


The RNA

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: hybridizes to ahrC mRNA and inhibits AhrC translation. PubMed

Extended information on the RNA

  • Kinetic information
  • Localization

Database entries

  • Structure:

Additional information

Information on the structure of the RNA can be found in Heidrich et al., 2006

The peptide

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: the peptide is conserved in bacilli
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry:
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: Repressed in the presence of glucose by CcpN PubMed
  • Regulatory mechanism: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant: 168 sr1::cat, available in Brantl lab
  • Expression vector:
  • lacZ fusion:

Labs working on this gene/protein

Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage

Your additional remarks

References

Nadja Heidrich, Isabella Moll, Sabine Brantl
In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA.
Nucleic Acids Res: 2007, 35(13);4331-46
[PubMed:17576690] [WorldCat.org] [DOI] (I p)

Nadja Heidrich, Alberto Chinali, Ulf Gerth, Sabine Brantl
The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism.
Mol Microbiol: 2006, 62(2);520-36
[PubMed:17020585] [WorldCat.org] [DOI] (P p)

Andreas Licht, Sven Preis, Sabine Brantl
Implication of CcpN in the regulation of a novel untranslated RNA (SR1) in Bacillus subtilis.
Mol Microbiol: 2005, 58(1);189-206
[PubMed:16164558] [WorldCat.org] [DOI] (P p)