SunS

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  • Description: sublancin S-glycosyltransferase

Gene name yolJ
Synonyms
Essential no
Product sublancin S-glycosyltransferase
Function biosynthesis of the antimicrobial peptide sublancin
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 49 kDa, 5.33
Gene length, protein length 1266 bp, 422 aa
Immediate neighbours bdbB, bdbA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YolJ context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

SP-beta prophage, membrane proteins, poorly characterized/ putative enzymes

This gene is a member of the following regulons

Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU21450

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • selectively modifies Cys22 in a 56-amino acid peptide substrate SunA and can accept a variety of NDP-sugars PubMed
  • Protein family: EngA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Huan Wang, Wilfred A van der Donk
Substrate selectivity of the sublancin S-glycosyltransferase.
J Am Chem Soc: 2011, 133(41);16394-7
[PubMed:21910430] [WorldCat.org] [DOI] (I p)

Trent J Oman, John M Boettcher, Huan Wang, Xenia N Okalibe, Wilfred A van der Donk
Sublancin is not a lantibiotic but an S-linked glycopeptide.
Nat Chem Biol: 2011, 7(2);78-80
[PubMed:21196935] [WorldCat.org] [DOI] (I p)

Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949] [WorldCat.org] [DOI] (P p)