Carbon core metabolism

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Genes in this functional category


see the structures of glycolytic enzymes Glycolytic enzymes: molecules of the month


Pentose phosphate pathway

TCA cycle

Overflow metabolism

Carbon core metabolism in SubtiPathways: Central carbon metabolism

Important original publications

Hanna Meyer, Hendrikje Weidmann, Ulrike Mäder, Michael Hecker, Uwe Völker, Michael Lalk
A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis.
Mol Biosyst: 2014, 10(7);1812-23
[PubMed:24727859] [] [DOI] (I p)

Frederik M Meyer, Jan Gerwig, Elke Hammer, Christina Herzberg, Fabian M Commichau, Uwe Völker, Jörg Stülke
Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon.
Metab. Eng.: 2011, 13(1);18-27
[PubMed:20933603] [] [DOI] (I p)

Roelco J Kleijn, Joerg M Buescher, Ludovic Le Chat, Matthieu Jules, Stephane Aymerich, Uwe Sauer
Metabolic fluxes during strong carbon catabolite repression by malate in Bacillus subtilis.
J. Biol. Chem.: 2010, 285(3);1587-96
[PubMed:19917605] [] [DOI] (I p)

Fabian M Commichau, Fabian M Rothe, Christina Herzberg, Eva Wagner, Daniel Hellwig, Martin Lehnik-Habrink, Elke Hammer, Uwe Völker, Jörg Stülke
Novel activities of glycolytic enzymes in Bacillus subtilis: interactions with essential proteins involved in mRNA processing.
Mol. Cell Proteomics: 2009, 8(6);1350-60
[PubMed:19193632] [] [DOI] (I p)

Simon Tännler, Eliane Fischer, Dominique Le Coq, Thierry Doan, Emmanuel Jamet, Uwe Sauer, Stéphane Aymerich
CcpN controls central carbon fluxes in Bacillus subtilis.
J. Bacteriol.: 2008, 190(18);6178-87
[PubMed:18586936] [] [DOI] (I p)

Anne Goelzer, Fadia Bekkal Brikci, Isabelle Martin-Verstraete, Philippe Noirot, Philippe Bessières, Stéphane Aymerich, Vincent Fromion
Reconstruction and analysis of the genetic and metabolic regulatory networks of the central metabolism of Bacillus subtilis.
BMC Syst Biol: 2008, 2;20
[PubMed:18302748] [] [DOI] (I e)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab. Eng.: 2003, 5(2);133-49
[PubMed:12850135] [] (P p)

H Ludwig, G Homuth, M Schmalisch, F M Dyka, M Hecker, J Stülke
Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon.
Mol. Microbiol.: 2001, 41(2);409-22
[PubMed:11489127] [] (P p)

U Sauer, V Hatzimanikatis, J E Bailey, M Hochuli, T Szyperski, K Wüthrich
Metabolic fluxes in riboflavin-producing Bacillus subtilis.
Nat. Biotechnol.: 1997, 15(5);448-52
[PubMed:9131624] [] [DOI] (P p)


Maria Papagianni
Recent advances in engineering the central carbon metabolism of industrially important bacteria.
Microb. Cell Fact.: 2012, 11;50
[PubMed:22545791] [] [DOI] (I e)

Yasutaro Fujita
Carbon catabolite control of the metabolic network in Bacillus subtilis.
Biosci. Biotechnol. Biochem.: 2009, 73(2);245-59
[PubMed:19202299] [] [DOI] (I p)

Abraham L Sonenshein
Control of key metabolic intersections in Bacillus subtilis.
Nat. Rev. Microbiol.: 2007, 5(12);917-27
[PubMed:17982469] [] [DOI] (I p)

Uwe Sauer, Bernhard J Eikmanns
The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria.
FEMS Microbiol. Rev.: 2005, 29(4);765-94
[PubMed:16102602] [] [DOI] (P p)

J Stülke, W Hillen
Regulation of carbon catabolism in Bacillus species.
Annu. Rev. Microbiol.: 2000, 54;849-80
[PubMed:11018147] [] [DOI] (P p)

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