fadR

fadR
168

transcriptional repressor (TetR family), regulation of fatty acid degradation

locus
BSU_28550
Molecular weight
21.83 kDa
pI
6.12
Protein length
Gene length
function
regulation of fatty acid degradation
product
transcriptional repressor
essential
no
synonyms
fadR, ysiA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,917,957  2,918,541
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Protein family
[wiki|TetR family]
[wiki|Domains]
[wiki|HTH tetR-type domain] (aa 5-65) (according to UniProt)
Structure
[PDB|3WHB] [pubmed|24356978]
[AF|P94548]
Effectors of protein activity
long chain fatty acids act as inducers that release FadR from its operator sites [Pubmed|24356978]
Expression and Regulation
Operons
genes
[gene|7AC5217CA35F8E134ABB35D74F1BA5E684D2E058|lcfA]-[gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]-[gene|3111ECB66CD3CFF0494AA3DF4D646102CF3B0FA8|fadB]-[gene|251600E5FD52DC0352A123F1224C037577F5A09C|etfB]-[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]
description
[Pubmed|17189250]
regulation
induced by long chain acyl-CoA (C14 ... C20) ([protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]) [Pubmed|17189250]
regulatory mechanism
[protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]: repression, [Pubmed|17189250], in [regulon|protein:8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|21398533], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21398533], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|7AC5217CA35F8E134ABB35D74F1BA5E684D2E058|lcfA]→[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]

2024-03-23 18:46:55

Jstuelk

62

d18d49394aac4cec0002a2695f8ea4b1c4cda4f5

DEE7D2778BB88C7028C79F5FEDED5CD757497033

genes
[gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]-[gene|3111ECB66CD3CFF0494AA3DF4D646102CF3B0FA8|fadB]-[gene|251600E5FD52DC0352A123F1224C037577F5A09C|etfB]-[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]
description
[Pubmed|17189250]
regulation
induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]
Open in new tab

[gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]→[gene|ACA8FF923D72CC99F447E47F6A1381FEAD9DAB09|etfA]

2024-03-23 17:41:44

ghost

58

079c8f1574d2e1a8270f558e4ec0295a90806447

FA5DAFE8C700F246311EFDCE5474D8DD396BEC38

Biological materials
Mutant
MGNA-B008 (ysiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1007 NBRP B. subtilis, Japan]
1A853 ( ''fadR''::''cat''), [Pubmed|17085570], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A853&Search=1A853 BGSC]
BKE28550 ([gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28550 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATGTTCATCGTTCCTTCC,  downstream forward: _UP4_AATAAGTAAAGGAGTTCTGT
BKK28550 ([gene|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28550 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATGTTCATCGTTCCTTCC,  downstream forward: _UP4_AATAAGTAAAGGAGTTCTGT
References
Reviews
17919287,24006471,38401830
Original Publications
17189250,21398533,24356978

8A8F93BAD0582F712C9EE1C3FE6C04292E91F390

Page visits: 5136

Time of last update: 2024-03-28 12:34:48

Author of last update: Jstuelk